Dr John ME Fell
Dr John Fell is a Consultant in Paediatric Gastroenterology at Chelsea and Westminster Hospital, (Hon Senior Lecturer Imperial College, London). He is currently director of subspecialty paediatrics at Chelsea and Westminster Hospital, and head of the paediatric gastroenterology service which is a regional service for the North Western sector of London.
His special interests are in the fields of enteral nutrition as a therapy for inflammatory bowel disease, and mucosal inflammation as it relates to gastrointestinal disease in infancy; in particular necrotizing enterocolitis and infantile colitides.
Dr Keith Lindley
Keith Lindley graduated in medicine from the University of London having obtained a BSc in Pharmacology during his medical studies. His post-registration years were spent mainly in Lonodon culminating in a PhD in Gastrointestinal Physiology at the UCL Institute of Child Health in 1992. Since then he has been senior member of the Gastoenterology Department at Great Ormond Street Hospital for Children NHS trust.
Currently he holds the position of Reader in Paediatric Gastroenterology and heads the Paediatric Neur ogastroenterology service at Great Ormond Street Hospital running the largest and busiest dedicated Paediatric clinical GI physiology laboratory in Europe providing a quaternary referral unit for paediatric GI motility disorders. Current Grant funded research interests include neuroimmun e interactions in the paediatric fore- and hind-gut, manipulation of the intestinal innate immune response by food proteins and host-pathogen interactions in campylobacter and C difficile infection.
He is a member of the editorial boards of the Journal of Pediatric Gastroenterology and Nutrition and Digestive and Liver Disease and co-editor of the European Society of Pediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) e-book project. He is convenor of the Gastroenterology Special Interest Group of the Physiological Society.
Professor Tom MacDonald
Tom MacDonald received a PhD in immunology from Glasgow in 1976 and then did a post-doc at the Trudeau Institute in upstate New York. In 1978 he was appointed as an assistant professor at Jefferson Medical College in Philadelphia and received tenure and promotion to Associate Professor in 1983. In 1984 he left Philadelphia and worked at Merck and Co for a year, before returning to Bart's Medical College in 1985. In 1986 he was appointed a Wellcome Trust Senior Lecturer at Bart's (until 1994), was promoted to reader in 1989, and given a personal chair at the University of London in 1991. In 2000 he moved to Southampton medical school to head up the Division of Infection, Inflammation and Repair and then in 2005 he returned to Barts and the London as Professor of Immunology and Dean for Research in the Medical and Dental School. He has over 400 publications, mostly on how inappropriate immune reactions cause disease in the human gut. His H-factor is 78 with almost 22,000 citations. He was awarded FRCPath in 1995 and FMedSci in 2002 on the basis of his published works. Achievements include indentifying that T cells cause coeliac disease and Crohn's disease, the role of TNF-alpha in IBD, with Nestle developing ModulenIBD to treat pediatric Crohn's disease, and identifying the critical role of Smad7 in chronic inflammation in Crohn's disease (antagonising Smad 7 in Crohn's disease is in phase III). He is working with GSK and Topivert on kinase inhibitors in IBD and compounds are going into man Q1 2015. He was a former associate editor of Gut and Gastroenterology and currently is an associate editor of Mucosal Immunology and the IBD journal. He has served on many grant awarding panels and advisory groups and is currently a member of the review panel of NC3R's, Action Medical Research, chairs the Mason Medical Foundation and Kings Health Partners Award panels, and was a past member of PSMB at MRC (2007-11) and currently chairs the MRC non-clinical training panel and is a member of the MRC careers and Training Panel.
Professor Simon Murch
His research background is in mucosal immunology, and his early work was based on the role of macrophage cytokines in intestinal and lung inflammation. This work contributed to the introduction of anti-TNF therapy in Crohn's disease, and also provided the first demonstration of the role of inflammatory cytokines in lung disease affecting preterm infants. His particular interests in food allergies include food-sensitive enteropathy and non lgE-mediated allergy. His recent work has shown evidence of impaired development of regulatory immune responses in allergic children, and future studies are planned to look at early infectious exposures to the intestinal flora as possible causes of impaired immunological priming. His additional work has focussed on the role of intestinal inflammation in childhood malnutrition disorders, and in the molecular basis of protein-losing enteropathy.
Dr David Rawat
Dr David Rawat has been an NHS Consultant Paediatric Gastroenterologist at Chelsea & Westminster Hospital, one of the biggest teaching hospitals for paediatric gastroenterology in London, since 2005. After completion of his training in London as a National Grid trainee for paediatric gastroenterology he also trained in Boston Children's Hospital, a Harvard Medical School Teaching Hospital where he consolidated his specialist interest in motility disorders. He is currently the lead clinician for GI motility disorders and endoscopy within the Department of Paediatric Gastroenterology at the Chelsea and Westminster Hospital providing a sub specialist paediatric GI motility service (tertiary and quartertiary referrals) for North West London. He has also been an Honorary Senior Lecturer for Imperial College London since 2005.
Dr Nikhil Thapar
Nikhil Thapar undertook his undergraduate medical training and intercalated BSc at Southampton University, qualifying in 1993 before going on to complete his MRCPCH and postgraduate paediatric training in the Wessex region. In 1998 he entered the national treasure specialist scheme in paediatric gastroenterology in London and in 2001 was awarded a research training fellowship from CORE (formerly Digestive Disorders Foundation) to undertake a PhD at the National Institute for Medical Research, London studying the therapeutic potential of stem cells for gut motility disorders. Following completion of the PhD in 2004 (University of London) he was awarded a Clinician Scientist post at the UCL Institute of Child Health and in 2006 appointed as honorary consultant in Paediatric Gastroenterology at Great Ormond Street Hospital. Dr Thapar, together with Dr Keith Lindley, runs a specialist clinical service for children with congenital and acquired gut motility disorders. Inherent to the service is a research team studying the pathogenesis and treatment of gut motility disorders with particular focus on molecular mechanisms (including allergy), harvesting and utilization of human enteric nervous system stem cells, and gut tissue engineering. Dr Thapar sits on the council of the British Society of Paediatric Gastroenterology Hepatology and Nutrition as research lead and is a member of the sub-specialty clinical studies group of the Medicines for Children Research Network.